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KMID : 1161420160190050518
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Journal of Medicinal Food
2016 Volume.19 No. 5 p.518 ~ p.520
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Chemical Composition and Antinociceptive Potential of Campomanesia reitziana Fruits
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Nesello Luciane Angela Nottar
Campos Adriana
Wagner Theodoro
Feliciano Arturo San
de Campos Buzzi Fatima
Filho Valdir Cechinel
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Abstract
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The methanolic extract from Campomanesia reitziana fruits and the main active principle, identified as 4′,6′-dihydroxy-3′,5′-dimethyl-2′-methoxy chalcone or dimethyl cardamonin (1), exhibited pronounced antinociceptive effects against two models of pain in mice. Compound 1 caused dose-dependent inhibition of abdominal constrictions, with a calculated ID50 value of 8.1 (6.5?10.1) μmol/kg (i.p.), being about 16-fold more potent than two reference analgesic drugs. Methanolic extract and 1 were also effective against the formalin model, inhibiting both phases of pain, causing reductions of 39.9% and 26.8% (extract, 10?mg/kg) and 52.9% and 57.6% (compound 1, 5?mg/kg) for the first and second phases, respectively.
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KEYWORD
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antinociception, Campomanesia reitziana fruits, chalcone, formalin model, writhing test
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